Objective: To research that Chinese Herbal Medicine (CHM) can treat Chronic Endometritis (CE) by regulating inflammatory cytokines and T-cell paradigm.
Materials and methods: 16 infertility women were selected in control group, others diagnosed CE were observed in the trial group. The levels of inflammation cytokines (IFNγ, IL-10, IL-17A and TGF-β) were analyzed, both the mRNA and protein expression of T cells subsets specific transcription factors (T-bet, GATA-3, RORγt and Foxp3) were detected.
Result: After CHM treatment, the expression of IFN-γ, IL-17AmRNA were low than the normal value while IL-10, TGF-βmRNA were high, both the mRNA and protein expression of T-bet and RORγt were lower than the healthy whereas GATA-3 and Foxp3 were higher.
Conclusion: CHM is a valid prescription for recommending CE. The mechanism may involve adjusting dynamic equilibrium of pro-inflammatory cytokines, anti-inflammatory cytokines and modulating Th1/ Th2, Th17/Treg paradigm shifting to Th2 and Treg.Author(s): Zhirong Zhang, Yiying Sun, Ning Zhang, Qinglan Qu, Hongchu Bao, Wenjuan Wang, Cuifang Hao