Objective: To investigate the diagnostic value of creatine kinase-myocardial band (CK-MB), myoglobin (Myo) and cardiac troponin T (cTnI) in acute myocardial infarction (AMI) and heart failure (HF).
Methods: Fifty patients with AMI, 50 HF patients and 50 normal subjects in hospital from January 2015 to December 2016 were enrolled. The levels of CK-MB, Myo and cTnI were measured for the analysis of heart failure NYHA classification. The levels of CK-MB, Myo and cTnIof AMI patients were measured at 2 h, 4 h and 6 h to analyze their specificity and sensitivity.
Results: The levels of CK-MB, Myo and cTnI in AMI group and HF group were significantly higher than those in normal group (P=0.0027, 0.0004, 0.0014<0.05). InAMI group, the sensitivity of Myo reached up to 65.54% and specificity 56.24% 2 h after onset. The sensitivity of CK-MB, Myo and cTnI 4 h after onset was 72.82%, 87.32% and 54.53% respectively, and the specificity was 75.62%, 82.48% and 58.43% respectively. The sensitivity of CK-MB, Myo and cTnI6h after onset was 100% and specificity was 88.46%, 95.32% and 90.24%, respectively. There was a significant difference in CK-MB, Myo and cTnI between I, II, III and IV levels of HF patients.
Conclusion: CK-MB, Myo and cTnI have good application value in the diagnosis of heart failure and the early diagnosis of acute myocardial infarction.Author(s): Junwei Wang, Feiyu Wang