ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences


Role of cholecystokinin receptors in carcinoma gallbladder

Cancer of the Gallbladder commonly occurs in elderly population and is fifth common can-cer in women. The aetiology of cancer gallbladder is not well understood. The present study was conducted to compare expression of the CCK receptors in the blood and gallbladder tis-sue in cases of cholelithiasis, cancer gallbladder and normal gallbladder. Forty- nine cases comprising 22 cancer gallbladders, 19 cholelithiasis and 8 normal gallbladders obtained from patients operated for biliary trauma or Whipple’s procedure. RNA extraction and cDNA formation for CCK-A and CCK-B receptors were carried out. Real Time PCR was performed. Both CCK-A and CCK-B receptors were expressed in all tissues and blood samples studied in the normal, cholelithiasis or carcinoma gallbladder. Although there was higher expression of CCK-A receptor in the cholelithiasis group as compared to normal group and decreased expression of CCK-A receptors in the carcinoma gallbladder group as compared to normal group yet this difference was not statistically significant. Conclusion: This is a preliminary study reported a comparative expression of cholecycstolinin receptors of gallbladder tissues and blood samples from patients with normal gallbladder, cholelithia-sis, and carcinoma gall bladder. The resulted insignificant data could possibly be due to small sample size. So far previous reports are not available to compare our results.

Author(s): Nisar A Ansari, Abhijit Chandra, SK Goel, Mohd Shazib Faridi
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