Objective: To investigate the effect of fluid resuscitation under the guidance of Pulse indicator Continuous Cardiac Output (PiCCO) on the immune function and inflammatory mediator in patients with septic shock.
Methods: From February 2016 to May 2017, 88 septic shock patients referred to our hospital were selected and randomly divided into two groups (control group and study group) with 44 cases in each group. The control group were given treatment of liquid recovery under the guidance of central venous pressure while the study group were treated with fluid resuscitation under the guidance of PiCCO. Changes in patient condition, peripheral blood CD4+/CD25+ T regulator cells (Treg), miR-155, IL-10 and ET-1 expression, hemodynamics and oxygenation parameters, mechanical ventilation time and ICU stay evaluation were compared between the two groups.
Results: Compared with the control group, the study group had better performance in condition changes, peripheral blood CD4+ CD25+ Treg, miR-155, IL-10 and ET-1 expression, hemodynamics and oxygenation parameters along with shorter duration of mechanical ventilation and ICU stay of statistical significance, P<0.05.
Conclusion: The fluid resuscitation under the guidance of PiCCO in septic shock enables the patients to have stable change of condition, better improvement of peripheral blood CD4+/CD25+ Treg, miR-155, IL-10, ET-1 expression, hemodynamics and oxygenation parameters and moderately short duration of mechanical ventilation and ICU stay, thus worthy of clinical reference.Author(s): Yongyuan Yao, Yanyan Guan, Yongling Zhuang, Wei Liu, Jian Cui, Yunbo Sun