ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

Abstract

Effects of different anesthesia and analgesia methods on postoperative Tlymphocyte, interleukin and hormone level of patients with esophageal cancer operation

Objective: This study was aimed to explore effects of different anesthesia and analgesia methods on postoperative T lymphocyteinterleukin and hormone level of patients with esophageal cancer operation.

Methods: From December 2015 to December 2016, a total of 134 patients with esophageal cancer were selected from our hospital as the study objects. All patients were divided into control group (n=67) and observation group (n=67). Patients in the control group were treated with epidural block anesthesia while patients in the observation group were treated with epidural block anesthesia combined with general anesthesia. T lymphocyteinterleukin and hormone level of patients in two groups at different periods of time (C1: 30 min before anesthesia, C2: skin incision of 2 h, C3: 2 h after operation, C4: 24 h after operation, C5: 48 h after operation) were analysed and compared.

Results: There were more CD4+ T lymphocytes in patients from observation group than those from control group at all periods (p<0.05). More CD8+ lymphocytes in the control group at C3 and C4 period (p<0.05), no difference at C1, C2 and C5 (p>0.05). Interleukin level in patient from control group was significantly lower than that in patients from observation group (p<0.05). Both PRL and GH level were lower in observation group at C2-C5 period and no difference at C1 stage and no significant difference of COR level was observed between two groups at all periods.

Conclusion: Epidural block anesthesia combined with general anesthesia is preferable during esophageal cancer operation.

Author(s): Mingxin Chen, Hongyin Du
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