Biomedical Research

Objective: To discuss over the clinical effect of treating subclinical varicocele induced infertility with varicocelectomy in combination with compound Xuanju capsule and the effect of the therapy on levels of sex hormone and anti-sperm antibody (AsAb). Methods: Eighty-eight patients with subclinical varicocele were selected and randomly divided into a treatment group and a control group (N=44). Patients in the control group underwent varicocelectomy, while patients in the treatment group were given compound Xuanju capsule besides surgery. Clinical effects, the level of sex hormone and the level of AsAb of two groups were observed and analyzed. Results: The clinical effective rate of the treatment group was 84.09%, much higher than 68.18% in the control group. Sperm density, the percentage of forward movement sperm and sperm survival rate of the control group were (29.32 ± 3.48) × 106, (45.68 ± 3.03) and (57.17 ± 3.42) respectively after treatment, much higher than the values before treatment, and the differences had statistical significance (P<0.05); the percentage of normal morphological sperms, sperm density, the percentage of forward movement sperm and sperm survival rate of the treatment group were much higher to those of the control group, and the differences had statistical significance (P<0.05); except for semen volume, the other indexes of the treatment group were superior to those of the control group after treatment, and the differences had statistical significance (P<0.05). The hormone level of the treatment group was higher than that of the control group, and the difference had statistical significance (P<0.05); the reduction amplitude of serum AsAb positive rate of the treatment group was more obvious than that of the control group, and the difference had statistical significance (P<0.05). Conclusions: Surgery in combination with compound Xuanju capsule can effectively improve semen quality and sexual hormone level and reduce the level of serum AsAb in the treatment of subclinical varicocele.

Author(s): Xiaowei Qu, Zhongjie Shan, Nan Zhang, Liang Guo
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