ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences


Acidic Xylooligosaccharide promotes recovery from iron deficiency anemia by enhancing serum iron level in rats

Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. A promo-tion function of mineral absorption has been reported for neutral oligosaccharides, but not acidic xylooligosaccharide (U-XOS), which is a novel oligosaccharide. We hypothe-sized that U-XOS could promote recovery from IDA by enhancing the serum iron level. Therefore, the aim of this study was to investigate whether or not U-XOS was useful for recovery from IDA in the rat. Twenty-four female Sprague-Dawley rats were randomly divided into a control group fed a control diet (4.0 mg Fe /100 g) and an IDA model group created by employing a low-iron diet (0.4 mg Fe /100 g). The IDA group was further di-vided into three subgroups on day 21: U-XOS-supplemented diet (LI-X, 4.0 mg Fe /100 g), low-iron diet (LI), and control diet (LI-C) groups. No significant differences in the serum iron transferrin saturation levels were demonstrated between the control and LI-X groups on days 26 and 35. The divalent metal transporter 1 and ferroportin mRNA expression levels shown in the first segment of the small intestines showed a significant decrease in the LI-X group, compared with the LI group. A significant decrease in the hepatic hep-cidin mRNA expression level and iron content was also demonstrated in the LI-X group, compared with the control group, but not compared with the LI group. These results sug-gested that U-XOS could promote recovery from IDA by enhancing serum iron at an early stage of the recovery process.

Author(s): Yukiko Kobayashi, Etsuko Wakasugi, Takayuki Ohbuchi, Meiko Yokoyama, Risa Yasui, Masa-shi Kuwahata, Yukihiro Nakabou, Yasuhiro Kido
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