ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

Silicosis-induced fibrosis: Pathogenesis, intervention and treatment

Joint Event on International Conference on Molecular Biology, Tissue Science and Regenerative Medicine & 4th World Heart Congress
November 19-20, 2018 | Paris, France

D Cheng Peng

Queensland Alliance for Environmental Health Sciences, Australia

Posters & Accepted Abstracts : Biomed Res

DOI: 10.4066/biomedicalresearch-C8-023


Long term exposure to silica can induce silicosis, a globe disease with higher incidence in developing countries. Although extensive efforts have been made, the molecular mechanisms remain to be fully elucidated for this disease. It is believed that the general process of the lung fibrosis includes the cell damage, formation inflammation, epithelial mesenchymal transition (EMT), extra cellular matrix and collagen deposition and consequent fibrosis. Due to the pathogenic complexity of the disease, together with the irreversibility of the fibrosis, silicosis is currently a progressive and incurable disease. Pharmacological treatment methods targeting on above process have been proved to be largely unsatisfactory. As an emerging treatment protocol, cell therapy through stem cell transplantation is promising in treatment of many disease including lung fibrosis. In this talk, the molecular mechanisms of silicosis, current treatment and our work to investigate the intervention effects of stem cells from various sources on the formation and development and lung fibrosis in animal model will be discussed.



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