Oudadesse H, Najem S, B Lefeuvre, Lucas-Gitot A and P Pellen
University of Rennes , France
Posters & Accepted Abstracts : Biomed Res
Recently, nanotechnology offers a new strategy to develop novel bioactive materials. Nanoscience are attractive in relation to regenerative medicine and tissue engineering approaches. Nanoparticles with size of 100 to 120 nm enhanced the interactions between cells and biomaterial surfaces. The higher specific surface area of nanoscale bioactive glasses allows faster release of ions and accelerates the deposition process of hydroxyapatite. Ternary bioactive glass nanoparticles (BGN) composed by SiO2 – CaO – P2O5 were prepared by a novel method based on a quick alkalimediated sol-gel method, in which the size of the bioactive glasses could be controlled. Particles size distribution of BGN has been determined by using dynamic light scattering (DLS). Obtained results show the size between 20 and 40 nm with an average of 36 nm. These sizes have been increased to 120 nm for biomedical applications according to the experimental method. Physicochemical characterization has been conducted by using several complementary techniques. The bioactive character of these BGN biomaterials was confirmed by using in vitro assays. Nanoparticles have been immersed in simulated body fluid (SBF) for different periods. The formation of hydroxyapatite layer was rapidly observed on the surface of BGN. Based on these results, this bioactive glass nanoparticle with excellent bioactivity would be a promising biomaterial for bone tissues engineering. After preparation and characterization, these BGN will be coated on metallic prosthesis using the electrophoresis method and associated with therapeutic molecules.