Lei Nie, Fang Zhang, Meng Sun, Jilai Cui and Hongyu Yuan
Xinyang Normal University, China
Posters & Accepted Abstracts : Biomed Res
In recent years, functional nanoparticles, have attracted attention due to their unique surface-ratio effects, small size and quantum size effects, and drug loading properties, etc. The phytochemicals present in tea have dual functions as effective reducing agents and can be used as stabilizers to provide strong coatings. The single step facile approach for using tea to synthesize metal nanoparticles in our lab. The drug-loading efficiency (such as doxorubicin hydrochloride, DOX) of metal nanoparticles were investigated, and the drug release profiles could be regulated by chemicals functionalized on the surface of nanoparticles. The toxicity of prepared nanoparticles on cells were evaluated. The results showed that the cells (HaCat, 293T, Hela) had a good viability while culturing with nanoparticles for three days. The metal nanoparticles prepared by using green tea have a good drugloading efficiency, and the cells could be killed at day three, shows that such drug-conjugated nanoparticles releasing system could be used in tumor cells applications.