Biomedical Research

EVALUATION OF [64Cu] PYRUVALDEHYDE-BIS (N4- METHYLTHIOSEMICARBAZONE) AN ATTRACTIVE RADIOPHARMACEUTICAL FOR MYOCARDIAL PERFUSION FOR PET

Joint Event on International Conference on CARDIOLOGY AND CARDIOVASCULAR MEDICINE & International Conference on STEM CELLS AND REGENERATIVE MEDICINE
June 18-19, 2018 | Osaka, Japan

Juan C Manrique Arias

Instituto Nacional de Cancerolog�­a & Universidad Nacional Aut�³noma de M�©xico, Mexico

Posters & Accepted Abstracts : Biomed Res

DOI: 10.4066/biomedicalresearch-C2-006

Abstract:

Copper (Cu) is an important trace element in humans; Due to its decay characteristics, Cu-64 (T1/2=12.7h, �²+ [17.4%], �²- [39%], E.C. [43.6%]) is an attractive radionuclide with applications in both, PET Copper molecular imaging and targeted therapy. This radionuclide has been widely used in the labelling of macromolecules such as peptides, proteins, monoclonal antibodies, and thiosemicarbazone complexes, [64Cu]Cu(II)-pyruvaldehyde-bis(N4-methyl-thiosemicarbazone) ([64Cu]Cu(II)- PTSM), a tracer for myocardial perfusion, Cu-64 is produced via the 64Ni(p,n)64Cu, nuclear reaction. [64Cu]-PTSM is prepared using in-house made PTSM ligand and [64Cu] chloride. Radiochemical purity of [64Cu]-Cu(II)-PTSM is higher than 98%. Cu(II) bis(thiosemicarbazone) complex as myocardial perfusion agents, labelled with positron emitters of Cu with half-lives suitable for its regional distribution from a satellite Centre.

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