Studies on the effect of malaria on serum lipid profile, total proteins alkaline phosphatase, certain micronutrients and some organs of the body were carried out using mice as experimental animal. Serum total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, total protein, alkaline phosphatase, manganese, zinc and copper were assessed in both control and test subjects. Significant decrease (P<0.05) was observed for serum total proteins in malaria infected mice when compared with control. Although, increased concentrations were observed for total cholesterol, HDL-C, triglyceride, LDL-C, alkaline phosphatase and zinc, however, the levels are not significant (P>0.05). Reduced concentrations were observed for manganese and copper, though not significant (P>0.05). Our observations support the hypothesis that malaria infections affect serum biochemical profiles.