The aim of present study was to quantify Serum - CRP and microalbuminuria in patients of acute chest pain and to find out correlation between CRP and microalbuminuria with chest pain. A hospital based cross sectional study was conducted on patients admitted in Emergency wards of Medicine Department of SGRRIMHS and Shri Mahant Indiresh Hospital, Dehradun (Uttarakhand). A total of 100 participants were included in the study. Out of which fifty patients of acute chest pain (33 male, 17 female) and 50 clinically healthy volunteers (29 male, 21 female) of similar age and sex were included in this study. Patients with respiratory diseases like pulmonary embolism, tuberculosis and pleurisy, gastro esophageal diseases like gall bladder, gastric and/or duodenal ulcer and diabetes mellitus, hypertension were excluded from the present study. All the participants were subjected to urinary examination for microalbuminuria and serum CRP estimation. Fifty patients in the age group 30-70 years and fifty clinically healthy age and sex matched volunteers (mostly staff members, their families and relatives of patients) were included in this study. Microalbumin in urine and CRP in serum was estimated by turbidometric methods. The mean serum CRP levels for male and female chest pain patients was calculated to be 33.91 ± 12.65 mg/l and 33.65 ± 15.57 mg/l respectively which was quite high as compared to the normal males 5.31±3.84 mg/l and female 6.39 ± 4.02 mg/l counter parts. Increase was more marked in female patients in comparison to their healthy counterparts exhibiting a gender differentiation in terms of CRP levels. The mean urinary albumin levels for male and female patients of acute chest pain was 29.39± 10.32 mg/l and 33.47±12.98 mg/l respectively which was found to be increased as compared to normal males with a value of 14.23 ± 9.92 mg/l and normal females 9.86 ± 5.96 mg/l respectively. Here again, the increase was more marked in female patients exhibiting gender differentiation again in terms of measured variables.