ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

Abstract

Physicochemical characterization of vancomycin and its complexes with ?-cyclodextrin

The equimolar complexes of vancomycin, a broad-spectrum glycopeptides antibiotic with β- cyclodextrin were prepared to evaluate their suitability for the development of a prolongedrelease form of the antibiotic. Complex preparations were subjected to kneading and freezedrying techniques and characterized using X-ray powder diffractometry (XRD), Thermogravimetric analysis (TGA), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The uniformity obtained from all of the analyzed results, suggests the successive formation of the aforementioned binary systems. The in vitro dissolution profiles of vancomycin were determined accordingly in a simulated cerebrospinal fluid where the results showed a modified release with improved bioavailabity of vancomycin was achieved upon complexation with beta-cyclodextrin. Our results therefore demonstrated that the use of cyclodextrin could be advantageous not only for lipophilic drugs but also for hydrophilic drugs.


Author(s): MS Zarif, AR Afidah, JM Abdullah, AR Shariza

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