It was a case control study of 60 subjects. The aim of this study was to compare the microproteinuria and other kidney functions between tobacco smokers and non-smokers, determining whether smoking is associated with an increased risk for chronic renal failure (CRF) overall and by type of renal disease. 60 subjects, in two different groups (30 in each) were studied in SSG hospital, Vadodara. 30 subjects were participated as a study group (Group II), with chronic tobacco smoking habits. 30 healthy participants, who had never used tobacco, were studied as control group (Group I). The assessment consisted of urine analysis for microproteinuria, creatinine clearance test and blood analysis for urea and creatinine level. Blood pressure and BMI were also evaluated. Both the groups were compared using the unpaired Student's t-test for significance. Both the groups did not differ significantly in sex structure and body mass index, but the blood pressure values were significantly higher in group II (SBP=120.6±8.6 vs 140.6±6.6 and DBP=76.8±4 vs 86±4.4). Group II participants were characterized by higher microproteinurea (61.53±12.9mg% vs. 241±20.3mg%; p<.0001), though there were no significant changes in other kidney functions. The smokers were significantly younger, which may points to the earlier origin of microproteinuria in smokers (42.1 +/- 11.0 years). We concluded that chronic tobacco consumption causes kidney damage in various manner, produces microproteinuria as an early predictor of renal diseases.