Glioblastoma Multiforme (GBM) is the most common primary malignant brain tumor. Median survival is usually less than 1 year from the time of diagnosis, and even in the most favorable situations, a majority of patients die within 2 years. Standard therapy consists of surgical resection, radiotherapy and chemotherapy. In this case report, we described a 38 y old woman with GBM survived 7 years after a series of treatments. For the patient, the tumor was found extensively infiltrate the sagittal sinus, the surgery unable completely remove of tumor, radiotherapy, chemotherapy and individualized anti-cancer herbs therapy were further applied. After all therapy, the patient was awake, with moderate bone window tension, palpable mass, right partial hemianopia, good right limb muscle strength. In summary, comprehensive treatment schedule including thorough surgical removal of tumor, systematic radiation, standard chemotherapy and individualized anti-cancer herbs therapy can help to prolong the survival of patients with GBM and gliosarcoma.