The aim of the study was to evaluate the status and diagnostic utility of PON1as indicator of antioxidant status in preeclampsia. Study groups involved cases, women with preeclampsia (BP >140/90mmHg, edema and proteinuria) (n=30) and controls, pregnant women without preeclampsia or any other complications attending hospital for antenatal checkup (n=30). Both cases and control groups were not on any vitamin E/ vitamin C supplementation. Fast-ing venous samples of blood were collected from both cases and controls. Serum PON1 and serum malondialdehyde (MDA) levels were measured spectrophotometrically. Students in-dependent‘t’ test and Pearsons correlation were used for statistical analysis. We found that PON1 activity in preeclampsia cases were significantly lower than in normal pregnancy con-trols while MDA levels were significantly higher. Conclusion: Our Study showed that the in-crease in Oxidative stress in preeclampsia cases is associated with a decrease in PON1 anti-oxidant activity.