Diabetes mellitus (DM) and Thyroid dysfunction, the two endocrine disorders have found to influence each other. The effects of which are poorly understood. Therefore, the present study was undertaken to understand the association trend of thyroid dysfunction with diabetic process and to assess the hyperglycemic effect by correlating fasting serum glucose (FSG) and thyroid profile parameters. 58 type 2 DM patients were studied for their thyroid profile along with their fasting glucose levels. Analysis was performed by comparing the values with age and gender matched controls using student ‘t’ test. Analysis showed that in type 2 diabetes mellitus patients, 7 (12.06%) patients had hypothyroidism and 18 (31.03%) subjects had subclinical hypothyroidism out of 58 subjects. Serum T3 and T4 hormone concentrations were low and Thyroid Stimulating Hormone (TSH) concentrations were high in Type 2 DM when compared to controls. But significant difference was found with T4 and TSH only (p value : <0.001). FSG did not show significant correlations with thyroid profile parameters. Type 2 Diabetes Mellitus patients are at risk for hypothyroidism and hence have to be followed up with serum TSH levels.