In this study, it was aimed to investigate the effects of zinc and CoQ10 supplements upon 8-week training programs. Totally 32 male players were included into the study. The players were categorized into 4 groups as only zinc supplement, only CoQ10 supplement, both zinc and CoQ10 supplement, and non-supplemented control including 8 each. Hemoglobin, hematocrit, erythrocyte, leucocyte and thrombocyte values of the experiments in both in rested and fatigue situations were determined. Obtained data were entered into SPSS 22.0 statistical software program, and subsequently, Friedman’s relational sample two-way variance analysis was used for determining the difference in groups. At the end of the statistical analysis, some increase in total WBC values was noticed between pre-test and post-test (p<0.01). No significant difference was observed in MCV, MCH, MCHC and Hb values. In terms of Htc value, more increase in post-tests was determined rather than the pre-tests (p<0.01). Consequently, it was concluded that Zinc and CoQ10 supplement did not create a significant difference upon the physiologic values in participants who were administered with short-medium term and medium-intensity exercise programs. It was possible to consider that higher performances of players could be obtained through long-term training programs administered with zinc and CoQ10.