ISSN: 0970-938X (Print) | 0976-1683 (Electronic)
An International Journal of Medical Sciences
Objective: To explore risk factors of cytologic positive rate of ascites in early endometrial cancer patients and its influences on prognosis.
Methods: 3415 endometrial cancer patients in I and II stage in endometrial cancer prevention and treatment of Ankang project in Guangdong Women and Children hospital from 2000 to 2010 were given ascites cytologic examination. Then this study analyzed the relations between ascites cytologic positive examination and clinical pathological conditions, the relations between ascites cytologic positive and patients’ prognosis.
Results: First, scites cytologic positive rate of early endometrial cancer patients was 3.7%. Second, single analysis show that the onset age more than 60 years old (P=0.008), deep muscle infiltration (P=0.001), cervical interstitial invasion (P=0.007), which were the influencing factors of ascites cytologic positive of early endometrial cancer patients. Multiple factors analysis show that onset age (OR=1.797, 95% CI 1.064~3.036, P=0.028), deep muscle infiltration (R=1.724, 95% CI 1.025~2.900, P=0.040), cervical interstitial invasion (OR=2.051, 95% CI 1.083~3.886, P=0.027) were independent risk factors of ascites cytologic positive of early endometrial cancer patients. Third, recurrence rate of positive and negative patients with ascites cytologic examination (14.2% vs. 7.2%, P=0.005), remote recurrence rate (11.0% vs. 4.5%, P=0.001), there were statistical differences, local recurrence rate (3.1% vs. 2.9%, P>0.05), there were no statistical differences. Fourth, survival time of ascites cytologic positive and negative patients compared with progress-free survival time, there were statistical differences (P<0.001, P=0.001). Multiple factors analysis showed that ascites cytologic positive had no obvious influences on survival time (OR=0.620, 95% CI 0.194~1.986, P=0.421) and progress-free survival time (OR=0.496, 95% CI 0.182~1.348, P=0.169).
Conclusion: Ascites cytologic positive has close relations with independent factors of old age, deep muscle infiltration, cervical interstitial invasion. The prognosis of scites cytologic positive patients poorer than negative patients, but scites cytologic positive isn’t independent prognostic influencing factors of early endometrial cancer.Author(s): Aiqin Wang, Hongqin Li, Yuanliang Li, Yujing Tian