ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

Research Article - Biomedical Research (2018) Volume 29, Issue 13

Relationship between periodontal diseases and bone diseases in some bone disease patients

Yu-Hee Lee1, Jung-Ok Choi2 and Seoul-Hee Nam3*

1Department of Dental Hygiene, Taegu Science University, Taegu, Republic of Korea

2Department of Dental Hygiene, Youngsan University, Yangsan, Republic of Korea

3Department of Dental Hygiene, College of Health Science, Kangwon National University, Samcheok-si, Republic of Korea

*Corresponding Author:
Seoul-Hee Nam
Department of Dental Hygiene, College of Health Science
Kangwon National University, Republic of Korea

Accepted date: June 19, 2018

DOI: 10.4066/biomedicalresearch.29-18-776

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Abstract

The purpose of this study was to identify factors that cause periodontal disease in patients with bone disease. The prevalence of periodontal disease in patients with osteoarthritis was investigated in 705 patients with osteoarthritis or osteoporosis among 5,945 adult specimens excluding the under 19 years of age based on the National Health and Nutrition Research Institute. The prevalence of periodontal diseases was found to be significantly different according to general characteristics of some bone disease and oral characteristics. As a result, the prevalence of periodontal disease tended to decrease with increasing income. The education level was similar to that of the undergraduate (43.0%) and the middle school graduate (45.4%), and the prevalence of periodontal disease tended to decrease as the number of high school graduates (31.1%) and college graduates (24.4%). The prevalence of periodontal disease was higher in patients without hypertension (33.8%) than in those without hypertension (46.1%). The prevalence of periodontal disease was higher (28.5%) than that of good oral health (46.8%). The prevalence of periodontal disease was significantly higher (p<0.05). The results of multiple logistic regression analysis were used to examine factors affecting periodontal disease. The results of the multiple logistic regression analysis showed that the higher the incomes, the higher the blood pressure, the better the subjective health condition, respectively. These results suggest that income levels, chronic disease management and use of oral hygiene products are effective in increasing the prevalence of periodontal disease and increasing oral health status in patients with bone disease. Therefore, dental hygienists should make oral health and oral hygiene education suitable for chronic disease management as well as oral health knowledge and make efforts to promote oral health.

Keywords

Bone disease, National health and nutrition research institute, Oral care product, Periodontal disease

Introduction

Osteoporosis is a systemic skeletal disorder that leads to increased bone flexibility due to decreased bone mass and microstructural destruction of the bone. In addition, it easily causes fracture even from a minor impact. In 1955, osteoporosis accounted for 18% of the total population, while 27% in 2010 and 35% by 2020 are estimated to be the risk group for osteoporosis [1]. The incidence and severity of osteoporosis increase with age, and it is expected that the number of patients will increase by the increase of average life expectancy in the future [2]. In addition to osteoporosis, osteoarthritis is a musculoskeletal disorder that affects approximately 10% of the world's population [3]. It is known to be accompanied by bone destruction associated with inflammatory cytokines [4].

Periodontal disease is an inflammatory disease that occurs in the tissues that surround the teeth. It is the major cause of tooth loss as gingival recession, formation of paradental cyst, and destruction of the periodontal ligaments and alveolar bone progress [5]. It is one of the chronic diseases ranked as third in the frequency of medical institution utilization [6]. According to the 2015 Korea National Health and Nutrition Examination Survey (KNHANES), 16.5% of males and 14.5% of females in their 30s were required to treat periodontal diseases even at a young age, and approximately 50% of males and 40% of females in their 50s or older showed a higher prevalence with the increase of age [7]. Alveolar bone loss is a typical symptom of periodontal disease, and severe osteoporosis has been reported to increase the severity of periodontal disease [8-11]. Many studies have been conducted on the relationship between bone disease and periodontal disease in the past. Klemetti [12] reported that osteoporosis is deeply involved in the alveolar bone resorption process, and Kribbs [13] mentioned that the density of mandibular bone was reduced and the cortical bone plate was thinned in persons with osteoporosis. It has also been reported that periodontitis and rheumatoid arthritis may be associated with each other in that inflammatory cell infiltration occurs, and they are mediated by cytokines [14,15].

The morbidity rates of bone disease and periodontal disease increase with age in both men and women worldwide, and these diseases have been studied in various ways [16]. As the population ages along with the development of medical science, the management of these two diseases, which increase rapidly with age, can be regarded as one of the essential conditions for a healthy life. Unlike in the past, the concept of health is understood in a comprehensive manner; therefore, it cannot be regarded as perfect health without proper oral health care [17]. If the teeth are lost due to oral diseases, it will result in a reduced chewing ability, and the range of food for consumption becomes limited, thereby leading to lowered quantity and quality of meals, which may result in the difficulty of maintaining good health and fitness.

In this regard, bone disease is a complication caused by fracture and bone destruction, thereby leading to high mortality and morbidity rates, and causing significant socioeconomic loss in medical costs. It is also considered to be a very serious disease for adults [18]. Hormonal imbalances and immune functions that change during this period may also increase the risk of periodontal diseases [19,20].

This study aims to investigate the prevalence of periodontal diseases in adults with bone disease by using the national data of the Korea National Health and Nutrition Examination Survey (KNHANES VI-3) based on the classification of data according to the general characteristics (e.g, gender, age, income, education level, and marital status), health care behaviors (e.g, BMI, subjective health state, smoking, drinking, hypertension, diabetes, menopause, etc.), and oral health characteristics (e.g, dental checkup status, dental visit, number of tooth brushing, use of dental auxiliary products, etc.), and analyzing them from multiple aspects. It also aims to provide fundamental data to maintain a healthy life in the aging society and improve the quality of life by lowering the incidence of periodontal diseases in patients with bone disease.

Materials and Methods

Study subjects

This study used raw data from the 6th Korea National Health and Nutrition Examination Survey (KNHANES VI-3) in 2015. Among a total of 7,380 samples, excluding the 1,435 samples under 19 years of age, 5,945 adult samples were extracted. Among them, 926 samples with osteoarthritis or osteoporosis were extracted. Excluding 221 patients, who had missing values in the main variables, 705 adults with osteoarthritis or osteoporosis were finally selected as the study subjects.

Survey methods

For this study, the IRB review was exempted (INJE 2017-08-005-003). From the raw data of KNHANES VI-3, gender, age, income, education level, marital status, subjective health state, Body Mass Index (BMI), smoking, drinking, hypertension, diabetes, menopause, calcium intake, stress, depression, suicidal ideation, dental check-up status, dental visit, gum disease treatment, tooth brushing status by period, subjective oral health, use of dental floss, use of interdental toothbrush, use of mouthwash, and presence of periodontal disease were utilized.

The age was divided into 19 to 29, 30 to 39, 40 to 49, 50 to 59, 60 to 69, and 70 and older. The marital status was classified into ‘married-spouse present’, ‘married-no spouse’, and ‘unmarried’. For the subjective health state, ‘very bad’ and ‘bad’ were classified as ‘bad’, while ‘average’, ‘good’, and ‘very good’ were classified as ‘good’. For the Body Mass Index (BMI), BMI values below 18.5 were classified as ‘underweight’, BMI values of more than 18.5 and less than 23.0 were classified as ‘normal’, BMI values of more than 23.0 and less than 25.0 were classified as ‘overweight’, and BMI values of 25.0 or more were classified as ‘obesity’. Smoking was categorized into 'current smoker', 'past smoker', and 'non-smoker'. Drinking was categorized into ‘not drinking alcohol’ and ‘drinking alcohol’ based on whether or not they consumed an alcoholic beverage for more than once a month. Calcium intake was categorized into intake of the recommended amount and intake of less than the recommended amount based on the recommended amount of calcium intake by age group suggested by the Korean Nutrition Society. The number of tooth brushing was calculated by summing up the periods of tooth brushing based on the tooth brushing status at each period, and the calculated number of tooth brushing was classified into 0-1, 2, 3, and 4 or more times. For the self-perceived oral health status, 'very poor' and 'poor' were classified as 'poor', while 'average', 'good', and 'very good' were classified as 'good' in order to perform statistical testing. The remaining variables other than these were used for the analysis without conversion.

Statistical analysis

In this study, a complex sample analysis was conducted because it used the raw data from KNHANES, which was extracted by using a stratified two-stage sampling design, rather than a simple random sampling design. Stratification and clustering variables were applied, and the complex sample design was made by applying the questionnaire and examination survey weighting.

Frequency analysis and descriptive statistics were performed in order to investigate the general characteristics and oral characteristics of the subjects. Chi-square tests were performed in order to identify the prevalence of periodontal diseases according to major variables. Meanwhile, a multiple logistic regression analysis was performed in order to examine the influences of general and oral characteristics of subjects with osteoporosis or osteoarthritis on periodontal diseases.

For the statistical analysis of this study, SPSS version 22.0 (IBM corp, Armonk, NY, USA) was used.

Results

Prevalence of periodontal diseases according to the health behaviors of the subjects

Frequency analysis and descriptive statistics were calculated in order to identify the general characteristics and health behaviors of the subjects. In terms of gender, 119 males (19.4%) and 586 females (80.6%) were included. As for the age, 19-29 y was comprised of 6 persons (1.6%), 30-39 y was comprised of 9 persons (2.6%), 40-49 y was comprised of 30 persons (6.6%), 50-59 y was comprised of 145 persons (24.9%), 60-69 y was comprised of 245 persons (30.2%), and 70 y or older was comprised of 270 persons (34.1%). As for the income, 259 persons (34.9%) fell under the lower level, 179 persons (23.5%) fell under the lower-middle level, 157 persons (23.6%) fell under the upper-middle level, and 110 persons (18.0%) fell under the upper level. In terms of the education level, elementary school or lower was comprised of 390 persons (51.3%), middle school was comprised of 114 persons (16.6%), high school was comprised of 133 persons (20.4%) and college or higher was comprised of 68 persons (11.6%). As for the marital status, married-spouse present was comprised of 452 persons (65.2%), married-no spouse was comprised of 243 persons (32.3%), and unmarried was comprised of 10 persons (2.5%). As for the subjective health status, 301 persons (42.3%) answered bad, while 404 persons (57.7%) answered good. In terms of BMI, underweight was comprised of 14 persons (2.4%), normal was comprised of 197 persons (27.9%), overweight was comprised of 178 persons (24.6%), and obesity was comprised of 315 persons (45.1%). As for smoking, 47 persons (8.5%) were current smokers, 89 persons (13.7%) were past smokers, and 569 persons (77.8%) were non-smokers. As for drinking, 484 persons (65.6%) were not drinking alcohol, while 221 persons (34.4%) were drinking alcohol.

Among the subjects, 322 persons (40.5%) had hypertension, while 383 persons (59.5%) did not have hypertension; and 109 persons (14.4%) were diabetic, while 596 persons (85.6%) were not diabetic. Furthermore, 533 persons (69.8%) experienced menopause, while 172 persons (30.2%) did not experience menopause; and 71 persons (10.2%) ingested the recommended amount of calcium, while 634 persons (89.8%) did not ingest the recommended amount of calcium. In addition, 187 persons (29.4%) experienced a lot of stress, while 518 persons (70.6%) were less stressed; 142 persons (20.0%) experienced depressive symptoms, while 563 persons (80.0%) did not experience depressive symptoms; and 56 persons (8.9%) had suicidal ideation, while 649 persons (91.1%) did not have suicidal ideation.

Chi-square tests were conducted in order to verify whether there was a significant difference in the prevalence of periodontal diseases according to the general and oral characteristics of the subjects.

As a result, the prevalence of periodontal diseases was significantly different according to income, education level, hypertension, and subjective health status of patients with osteoarthritis or osteoporosis (p<0.05).

The prevalence of periodontal diseases according to income was 46.0% for the lower level, 45.1% for the lower-middle level, 30.2% for the upper-middle level, and 27.9% for the upper level, thereby indicating that the prevalence was likely to decrease as the income increased. As for the prevalence of periodontal diseases according to education level, the prevalence was similar in elementary school or lower (43.0%) and middle school graduate (45.4%), and it was likely to become lower as the education level increased to high school (31.1%) and college or higher (24.4%). In terms of hypertension, the prevalence of periodontal diseases was higher in patients with hypertension (46.1%) than in those without hypertension (33.8%). In regard to the subjective oral health status, the prevalence of periodontal diseases was higher when the subjective oral health status was bad (46.8%) than when it was good (28.5%) (Table 1).

Variables Group N (%) Periodontal disease p*
No Yes
Sex Male 119 (19.4) 58 (56.5) 61 (43.5) 0.312
Female 586 (80.6) 364 (62.3) 222 (37.7)
Age 19-29 6 (1.6) 6 (100.0) 0 (0.0) 0.128
30-39 9 (2.6) 7 (72.8) 2 (27.2)
40-49 30 (6.6) 21 (67.2) 9 (32.8)
50-59 145 (24.9) 93 (68.1) 52 (31.9)
60-69 245 (30.2) 146 (58.2) 99 (41.8)
70 270 (34.1) 149 (55.0) 121 (45.0)
Income Low 259 (34.9) 138 (54.0) 121 (46.0) 0.006
Mid-low 179 (23.5) 97 (54.9) 82 (45.1)
Mid-high 157 (23.6) 107 (69.8) 50 (30.2)
High 110 (18.0) 80 (72.1) 30 (27.9)
Education ≤ Elementary 390 (51.3) 220 (57.0) 170 (43.0) 0.022
Middle 114 (16.6) 61 (54.6) 53 (45.4)
High 133 (20.4) 90 (68.9) 43 (31.1)
≤ College 68 (11.6) 51 (75.6) 17 (24.4)
Marriage Spouse 452 (65.2) 283 (64.6) 169 (35.4) 0.169
No spouse 243 (32.3) 132 (54.1) 111 (45.9)
Not married 10 (2.5) 7 (64.7) 3 (35.3)
Subjective health Bad 301 (42.3) 191 (63.6) 110 (36.4) 0.351
Good 404 (57.7) 231 (59.5) 173 (40.5)
BMI Low weight 14 (2.4) 7 (41.0) 7 (59.0) 0.484
Normal 197 (27.9) 121 (62.0) 76 (38.0)
Overweight 178 (24.6) 100 (64.1) 78 (35.9)
Obesity 315 (45.1) 193 (60.0) 122 (40.0)
Smoking Current 47 (8.5) 21 (49.2) 26 (50.8) 0.21
Past 89 (13.7) 47 (57.4) 42 (42.6)
Non-smoker 569 (77.8) 354 (63.2) 215 (36.8)
Drinking No 484 (65.6) 290 (61.7) 194 (38.3) 0.749
Yes 221 (34.4) 132 (60.2) 89 (39.8)
Hypertension No 383 (59.5) 241 (66.2) 142 (33.8) 0.009
Yes 322 (40.5) 181 (53.9) 141 (46.1)
Diabetes No 596 (85.6) 350 (60.0) 246 (40.0) 0.196
Yes 109 (14.4) 72 (68.0) 37 (32.0)
Menopause Men or no 172 (30.2) 96 (60.8) 76 (39.2) 0.903
Yes 533 (69.8) 326 (61.4) 207 (38.6)
Calcium intake Not enough 634 (89.8) 378 (60.9) 256 (39.1) 0.671
Enough 71 (10.2) 44 (63.8) 27 (36.2)
Stress No 518 (70.6) 303 (59.8) 215 (40.2) 0.333
Yes 187 (29.4) 119 (64.6) 68 (35.4)
Depression No 563 (80.0) 336 (61.4) 227 (38.6) 0.865
Yes 142 (20.0) 86 (60.5) 56 (39.5)
Thought about suicide No 649 (91.1) 388 (60.8) 261 (39.2) 0.637
Yes 56 (8.9) 34 (65.0) 22 (35.0)
Values are presented as number (weighted %); *calculated by chi-square test

Table 1: Difference of periodontal disease according to general and oral behavior (N=705).

Prevalence of periodontal diseases according to the oral characteristics

Among the subjects, 187 persons (27.8%) had oral health check-up from the previous year, while 518 persons (72.2%) did not have oral health check-up from the previous year; 419 persons (59.4%) had a dental visit, while 286 persons (40.6%) did not have a dental visit; and 138 persons (19.8%) had gum disease, while 567 persons (80.2%) did not have gum disease. The number of tooth brushing was 0-1 time in 81 persons (10.1%), 2 times in 337 persons (49.2%), 3 times in 200 persons (28.7%), and 4 or more times in 87 persons (12.0%). The subjective oral health status was good in 313 persons (43.8%) and bad in 392 persons (56.2%). Moreover, 99 persons (16.1%) used dental floss, while 606 persons (83.9%) did not use dental floss; 95 persons (15.1%) used an interdental toothbrush, while 610 persons (84.9%) did not use an interdental toothbrush; and 155 persons (23.2%) used a mouthwash, while 550 persons (76.8%) did not use a mouthwash. Meanwhile, 283 persons (38.8%) had periodontal diseases, while 422 persons (61.2%) did not have any periodontal diseases.

The prevalence of periodontal diseases according to the use of dental floss was not significant based on the significance level of 5%, but it showed a significance probability (p-value) close to the significance level (Table 2).

Variables Group N (%) Periodontal disease p*
No Yes
Dental examination in a year No 518 (72.2) 309 (60.6) 209 (39.4) 0.631
Yes 187 (27.8) 113 (62.8) 74 (37.2)
Visit dental clinic in a year No 286 (40.6) 166 (59.6) 120 (40.4) 0.536
Yes 419 (59.4) 256 (62.3) 163 (37.7)
Gum disease treatment No 567 (80.2) 339 (60.6) 228 (39.4) 0.546
Yes 138 (19.8) 83 (63.7) 55 (36.3)
Tooth brushing frequency 0-1 81 (10.1) 48 (58.7) 33 (41.3) 0.778
2 337 (49.2) 197 (60.5) 140 (39.5)
3 200 (28.7) 123 (61.0) 77 (39.0)
4 87 (12.0) 54 (66.7) 33 (33.3)
Subjective Good 313 (43.8) 209 (71.5) 104 (28.5) <0.001
Oral health Bad 392 (56.2) 213 (53.2) 179 (46.8)
Use of floss No 606 (83.9) 349 (59.2) 257 (40.8) 0.057
Yes 99 (16.1) 73 (71.6) 26 (28.4)
Use of interdental brush No 610 (84.9) 359 (61.1) 251 (38.9) 0.939
Yes 95 (15.1) 63 (61.6) 32 (38.4)
Use of gargle No 550 (76.8) 319 (60.3) 231 (39.7) 0.417
Yes 155 (23.2) 103 (64.3) 52 (35.7)
Values are presented as number (weighted %); *calculated by chi-square test.

Table 2: Difference of periodontal disease according to oral characteristics (N=705).

Analysis of factors affecting periodontal diseases

Multiple logistic regression analysis was performed in order to test the factors affecting periodontal diseases in osteoarthritis or osteoporosis patients (Table 3). For the independent variables, income, education level, hypertension, and self-perceived oral health status, which were significant at the chi-square tests, were entered, and the use of dental flow that showed a significance probability close to the significance level was also included. For the dependent variables, the presence of periodontal diseases was entered, and ‘normal (no periodontal diseases)’ was set as the reference category.

Variables OR 95% CI p*
Income Low 1.581 1.219-2.050 0.001
Mid-low 1.372 1.089-1.729 0.008
Mid-high 1.084 0.853-1.376 0.509
High 1    
Education ≤ Elementary 1.096 0.828-1.449 0.521
Middle 1.291 0.981-1.699 0.068
High 1.124 0.884-1.428 0.338
≤ College 1    
Hypertension No 1    
Yes 2.79 2.323-3.352 <0.001
Subjective oral health Bad 1    
Good 0.426 0.363-0.500 <0.001
Use of floss No 1    
Yes 0.628 0.510-0.772 <0.001
Values are presented as number (weighted %); *calculated by multiple logistic regression analysis

Table 3: Factors affecting periodontal disease of arthritis patients.

As a result, the likelihood of having periodontal diseases was higher when the income level was lower (OR=1.581, p<0.01) and lower-middle (OR=1.372, p<0.01), as compared to the upper level. The education level did not significantly influence periodontal diseases. Patients with hypertension was 2.790 times more likely to develop periodontal diseases (OR=2.790, p<0.001). When the subjective oral health status was good, the likelihood of having periodontal diseases was as low as approximately 42.6% level (OR=0.426, p<0.001). In the case of using dental floss, the likelihood of having periodontal diseases was as low as approximately 62.8% level (OR=0.628, p<0.001).

It was concluded that the patients with osteoarthritis or osteoporosis have a lower likelihood of having periodontal diseases when they have a higher income, no hypertension, good subjective health status, and a habit of using dental floss.

Discussion

Several countries worldwide have selected representative oral diseases that should be managed in order to improve the oral health of the people by investigating the causes of tooth extraction. In almost all countries, dental caries and periodontal diseases were the main causes of tooth loss [21-23]. Oral disease cannot be fully recovered once it occurs; therefore, proper management is more required as compared to any other diseases [24]. Osteoporosis and osteoarthritis, which are thought to be related to periodontal diseases, are caused by the decrease in bone mass, and may cause bone weakness and fracture. It has also been reported that the reduction of bone mass itself does not cause any symptoms, but once there is a fracture, pain, loss of function, and deformity may occur [25]. There may be some similarities and causal relationships between the two diseases that are expected to increase in the aging society with an increased average life expectancy. Therefore, the purpose of this study is to investigate the factors affecting the prevalence of periodontal diseases and to provide fundamental data for the prevention and maintenance of the oral health of patients with bone disease.

In terms of the prevalence of periodontal diseases according to the income among the general characteristics of the subjects, the prevalence had the tendency to decrease as the income increases from the lower (46.0%), lower-middle (45.1%), and upper-middle (30.2%) to the upper level (27.9%). This result was consistent with those of Won et al. [26] and Lee at al. [27]. This is because the higher the income, the better the information acquisition and the better the utilization of medical institutions. Therefore, it is necessary to provide information and opportunities to receive medical services equally for various classes of patients. As for the education level, the prevalence of periodontal diseases had the tendency to become lower as the education level becomes higher at 31.1% in high school graduates and 24.4% in college graduates or higher. This is similar to the result that the lower the level of education, the lack of knowledge about oral health or lack of awareness for oral disease prevention. In regard to the prevalence of periodontal diseases according to health behavior, the prevalence was high in hypertensive patients, which is similar to the result of the previous study conducted by Cheon et al. [24]. On the other hand, there was no significant outcome in the relationship between the use of oral care products and periodontal diseases in the prevalence of periodontal diseases according to oral characteristics. In this study, although the use of oral care products did not show a statistically significant relationship, it is thought that education on the proper use of oral care products by dental hygienists is urgently needed because continuous and proper use of oral care products will gradually help in the prevention and management of periodontal diseases.

The analysis of relevant variables affecting periodontal diseases in patients with bone disease showed statistically significant results in low income, hypertension, subjective oral health status, and use of dental floss. First, in terms of income, the prevalence of periodontal diseases increased by 1.5 times and 1.3 times, respectively, when the income was lower and lower-middle, as compared to the upper level. The result of this study is similar to those of Won et al. [26] and Cheon et al. [24]. The role of dental hygienists in oral health activities and delivery of oral health information for low-income people can be very important, and the active promotion of measures to intensively manage periodontal diseases in the subjects is necessary. In addition, hypertension is associated with a higher incidence of periodontal diseases (2.790-fold), which is consistent with the results of Baek et al. [28] and Park et al. [29]. Oral health care is essential for all ages in the life cycle. However, patients with hypertension, which is a chronic disease, are more likely to develop periodontal diseases. For this reason, intensive periodontal disease management programs will be needed for hypertensive patients. In patients with a good subjective health status, there is a likelihood of having periodontal diseases lowered to approximately 42.6% level. In the case of using dental floss, there is a likelihood of having periodontal diseases lowered to approximately 62.8% level. The use of dental floss seems to prevent periodontal diseases by selectively and intensively managing difficult areas.

This study has a limitation in that it is a cross-sectional study using the raw data of KNHANES VI-3. However, this study has its significance in that it conducted an analysis with the most recent data, and general characteristics, health behavior, and oral characteristics were investigated from multiple aspects.

Conclusion

In summary, the management of systemic diseases and the use of oral care products are important factors with regard to the prevalence of periodontal diseases in patients with bone disease. This study result ultimately contributes not only to the enhancement of the oral health for patients, but also the improvement of their quality of life by carrying on a healthy lifestyle in an aging society. It is important to develop various programs that deliver information on the prevention and management of periodontal diseases in chronic patients, proper use methods of oral care products, oral health knowledge for low-income people, and the role of dental hygienists who cultivate professional oral care knowledge in the program operation.

Acknowledgements

This work was supported by Youngsan University Research Fund of 2018.

Conflict of Interest

The authors report no conflicts of interest related to this study. The author does not have any financial interest in the companies whose materials are included in the article.

References