Current knowledge on the pharmacotherapy of acute myocardial infarction (AMI) has been limited with various cellular factors. The present research perspectives are mainly focusing on the efficacy of different antiplatelet therapy to treat the AMI. Ticagrelor has been proved as a better therapeutic choice for treating AMI when compared to clopidogrel and prasugrel. Proinflammatory cytokines like TNF-α, IL-1β and IL-6 are released during infarction and plays pleiotropic mode of action that induces cell damage and also involved in cell protection. However, the available data on the cytokine network during antiplatelet therapy is inadequate. This review method is based on the search of various search engines such as PubMed Central, PubMed, Scopus, Medline, Research Gate to capture many articles and we examined the importance of cellular factors and ticagrelor in AMI. Thus, the present review analyses the role of cytokine network during the treatment of AMI which is an important key factor to understand the essential cellular mechanism of cardiomyocytes and the effect of ticagrelor on proinflammatory cytokine network during the therapeutic phase of AMI.