Biomedical Research

Objective: To investigate the relationship between CT features of Peripheral Non-Small Cell Lung Cancer (PNSCLC) and gene mutation of Epidermal Growth Factor Receptor (EGFR).

Methods: 60 PNSCLC samples with complete clinical data and affirmed by histopathological examination in our hospital. All the histological or cytological specimens were subjected to the Amplification Refractory Mutation System (ARMS) or gene sequencing method for EGFR mutation situation. The relationship between CT features and EGFR gene mutation was evaluated with each patient’s chest radio-graphic examination.

Results: 60 PNSCLC, 29 cases of EGFR gene mutation, including 53.3% of women and 55.6% of nonsmokers. CT amplification of the EGFFR gene mutation was 49.07 ± 12.57 Hu. Non-EGFR gene mutation was 38.43 ± 13.93 Hu. By comparing the data, the difference was highly significant (P<0.01). With CT angiography, pleural depression and bone metastasis, gene mutation rate and non-gene mutation rate were 33.3%, 66.7%, 38.5%, 61.5%, 70.6%, 29.4%, respectively. The difference was considerable (P<0.05). With CT deep subdivision, fine short burrs, pleural effusion and other metastatic signs, the difference between gene mutation rate and non-gene mutation rate was not significant (P>0.05).

Conclusion: In PNSCLC, CT amplification of the EGFR gene mutation is significantly higher. The EGFR gene mutation with bone metastasis is higher, and EGFR gene mutation is low.

Author(s): Ninglu Yuan, Xiaohe Zhang, Zhitao Lu, Yimeng Fan, Hongmei Gao
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