The aim of this study is to compare the promoting effects of Platelet Rich Plasma (PRP), Silver Alginate (AgS), and intralesional Epidermal Growth Factor (EGF) in burn wound healing through the use of 56 rats equally divided into four groups. The control group was given only saline (SF). Except for AgS, all of the drugs were administered by the intralesional route on the first, third, and fifth days of the experiment. Half of the rats in each group were euthanized on the 14th day and the remaining rats were kept for 21 days to observe the wound healing process. The excised specimens were fixed in a 10% neutral buffered formalin solution for pathological evaluation. In the PRP group, fibroblastic activity and neoangiogenesis decreased between 14 and 21 days while Collagen Deposition (CD) increased. In the EGF group, Fibroblast Proliferation (FP), CD, and neoangiogenesis increased between 14 and 21 days. The correlation was found to be directly proportional to this increase. In the Ag sulfadiazine group, FP and neoangiogenesis did not increase between 14 and 21 days while CD increased slightly. All three drug groups induced wound healing. While Ag sulfadiazine showed uncontrolled wound healing, PRP stimulated more efficient healing in the acute phase and EGF stimulated a more slowly progressing wound healing.