ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

Abstract

The optimization of the production conditions of gamma aminobutyric acid by Absidia fermentation

Gamma Aminobutyric Acid (GABA), also known as 4-aminobutyric acid, of which the molecular formula is C4H9NO2, with a relative molecular weight of 103.2. It widely exists in the cells of microorganism, animals and plants, as a kind of neuro-inhibitory transmitter in mammals, a variety of physiological and metabolic activities are involved. It is greatly demanded by the market for the special physiological function and medicinal value with its unique molecular structure: it has the function of lowering blood pressure, treating epilepsy, enhancing memory, anti-sleeping and delaying senescence, with higher physiological activity. We used Absidia as the fermentation strain, and found out the best fermentation conditions: temperature: 31°C; time: 70 h; pH value: 4.9; inoculation age: 18 h, inoculation amount: 8%, rotation speed: 170 r/min. When the fermentation test was performed according to the conditions, the molar conversion rate of GABA can reach 32.03%, this can provide theoretical support for large-scale industrial production in the future.


Author(s): Zhichao Wang, Yufen Xiao, Wensong Wang, Zhifei Wang

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