In the present century, the decline of bone mineral density (BMD) and osteoporosis is a silent epidemic. The objective of the current study was to estimate the effect of vitamin C on BMD in menopausal women with balanced diet. Randomized, controlled clinical trial (RCT) was conducted as per WHO Registry Network. The study was done in Hafez Hospital of Shiraz University of Medical Sciences, Shiraz, Iran. 150 menopausal women suffering from osteoporosis were chosen. In randomized block design, the individuals were placed in the vitamin C (test) and placebo (control) groups. The test group received orally 1000 mg of vitamin C in two divided doses for 6 months and the control group similarly had placebo. Test parameter: Bone mineral density (BMD). Before treatment, considering some demographic specifications and the results of BMD were not different statistically (P>0.05) but there was significant difference in the age and obstetric history (p<0.05). There was a significant correlation between obstetric history with lumbar BMD (r= -295 and P<0.001) and femoral BMD (r= -0.226 and P=0.006). The average vertebral BMD did not indicate any significant difference between the vitamin C-treated group (0.02±0.05, P=0.001) and the controls (0.02±0.04, P<0.001). With respect to the findings of the study about the effects of vitamin C on BMD, antioxidant is suggested to add to the current treatments.