Inflammation is the most common symptom for patients after oral implantology. Evidences have indicated that resveratrol plays ameliorative effects on higher inflammatory factor concentration and metabolic syndrome. In this study, we investigated the therapeutic effects of resveratrol on patients after oral implantology. A total of 162 patients after oral implantology were recruited in this study and inflammatory cytokines were analyzed after treatment with resveratrol or placebo during 4-week observation. RT-qPCR and ELISA were used to the measure changes of inflammatory cytokines in oral implantology patients after resveratrol. Results showed that mRNA and serum levels of IL-1β, IL-17A and tumor necrosis factor alpha (TNF-α) were decreased by Resveratrol treatment in patient after oral implantology. It demonstrated that mRNA and serum levels of IL-2, IL-6 and IL-10 were up-regulated by resveratrol in patient after oral implantology. Notably, we found that resveratrol treatment markedly decreased intercellular adhesion molecule-1 (ICAM-1) and immunoglobulin A1 (IgA1) expression levels for patients after oral implantology.