Biomedical Research

Psychological health of Chinese healthy volunteers was investigated to provide a theoretical method for phase I clinical trial management and result analysis. Symptom checklist 90 (SCL-90) and Eysenck Personality Questionnaire (EPQ) were used to assess 200 healthy volunteers and to analyse the level of psychological health of Chinese healthy volunteers. SCL-90 result indicates that the average value of positive factors is 10.32 ± 14.26 by self-assessment of healthy volunteers, somatization factor is 1.13 ± 0.13, compulsive symptom factor is 1.29 ± 0.27, interpersonal sensitivity factor is 1.31 ± 0.21, depression factor is 1.26 ± 0.33, anxiety factor is 1.21 ± 0.21, hostility factor is 1.08 ± 0.26, phobia factor is 1.05 ± 0.18, paranoid factor is 1.12 ± 0.23, psychotic symptom factor is 1.17 ± 0.26. Comparing the norm in China, the score of each factor of healthy volunteers is relatively low with statistically significant difference (P<0.001). EPQ result shows that P score is 4.59 ± 2.33, E score is 13.13 ± 4.32, N score is 6.89 ± 5.26, and L score is 13.21 ± 4.25 for 200 healthy volunteers. Comparing the norm in China, the P and N scores are lower, and the E and L scores are higher, with statistically significant difference (P<0.001).

Author(s): Yudong Wei, Haiyan Li, Huali Wang, Shuang Zhang, Yumei Sun
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