Background: The pathogenesis of acne vulgaris is multifactorial and inflammation plays a prominent role in the process. In clinical trials, independent from tissue type; it is found out that prolidase levels and activity are differing in numerous malign and chronic inflammatory processes on which collagen turnover is accelerated. This study aims to evaluate the relationship between serum prolidase levels and acne severity in acne vulgaris.
Methods: Thirty patients with mild to moderate Acne Vulgaris (AV), 30 with severe AV and 28 healthy volunteers were included in the study. The GAS was used to determine disease severity in patients with AV. Serum prolidase levels were measured by ELISA method.
Results: There were not statistically different between the groups in term of serum prolidase levels (p=0.819). In addition, there was no statistically significant difference between the two groups (p=0.647 for AV groups, p=0.926 for severe AV and healthy control, and p=0.539 for mild-moderate AV and healthy control). There was no statistically significant correlation between GAS and prolidase levels in patients with severe AV (r=0.207, p=0.273) and mild-moderate AV (r=0.162, p=0.392).
Conclusions: In conclusion, there was no significant difference in serum prolidase levels in patients with AV. New studies with wide case series are necessary to determine the role of prolidase on the pathogenesis of acne vulgaris.