The present study of screening for gestational diabetes mellitus was carried out in 500 preg-nant women attending OPD section of Gynecology Department at Pravara Institute of Medical Sciences, Loni. The high risk patients underwent glucose challenge test with 75 gm glucose, between 14-16 weeks of gestation and if negative the test was again done after 28 weeks. Out of 500 pregnant women, 117 individuals with abnormal glucose challenge test were subjected to 2 hr- 75gm oral glucose tolerance test (OGTT). Sensitivity of oral glucose tolerance test in detection of gestational diabetes in high risk group was determined. The screening of high risk group was done with the help of OGTT, which required no extra laboratory facilities, long waiting period or trained manpower. It has no side effects but guarantees good compliance of patient. OGTT hence is a reliable method to detect gestational diabetes mellitus in high risk group.