Biomedical Research

Objective: To evaluate relevant risk factors for adverse fetal outcomes among patients with Intrahepatic Cholestasis of Pregnancy (ICP).

Methods: We performed a retrospective analysis, data were obtained for all women with ICP admitted to hospital between January 2014 to December 2015. Patients were divided into group A (no adverse fetal outcomes) and group B (adverse fetal outcomes). They were further divided into mild ICP and severe ICP on the basis of severity. The frequency of adverse fetal outcomes was assessed.

Results: Among 313 eligible women, 223 (71.2%) were mild ICP and 90 (28.8%) were severe ICP. By multivariate regression logistic analysis, Total Bile Acid (TBA) and twin pregnancy were the risk factors for adverse fetal outcomes among patients (p=0.001 and p<0.001, respectively). Receiver operating characteristic curve analysis revealed that the level TBA could be used as a predictor of adverse fetal outcomes with a 59.7% sensitivity and a 56.3% specificity when the cut-off value was 24.1 μmol/L at the time of diagnosis of ICP.

Conclusion: Patients with severe ICP, twin pregnancy and high TBA level should be considered more intensive surveillance for possible adverse fetal outcomes.

Author(s): Li Li, Lin Cong, Yuanhua Chen, Yuanyuan Yang
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