Biomedical Research

This research studied the protective effect of New Fuzheng Chuyi Granule (NFCG) on the lung tissue of mice with acute upper respiratory tract infection (AURI) and its mechanisms. A mouse model of AURI was established by intranasal instillation of Streptococcus pneumoniae, and high-dose (5.28 g/kg), medium-dose (2.64 g/kg) and low-dose (1.23 g/kg) of NFCG were intragastrically given to the mice, respectively, and on the 1^st, 4^th and 7^th day after the administration, lung wet/dry weight ratio and lung index were calculated, pathological changes of the lung tissue and the spleen lymphocyte proliferation were observed, and TNF-α, IL-6, IL-1, IFN-γ, TLR2, TLR4, MyD88, and NF-κB expressions in the lung tissue were detected. The results showed that NFCG could reduce the lung wet/dry weight ratio and the lung index, alleviate the pathological changes in the lung tissue, and increase the spleen lymphocyte proliferation in mice; in addition, NFCG could reduce the expression of several pro-inflammatory factors, including TNF-α, IL- 6, IL-1 and IFN-γ, and TLR2, TLR4, MyD88 and NF-κB proteins. These results suggest that NFCG can protect the lung tissue of mice with AURI, which may be related to its improving the immunity, anti-inflammation and regulation of TLR2/4-MyD88 signaling pathway.

Author(s): Xin Su, Shuang Jiang, Guang Yang, Xiaoyan Gong
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