The objective of the present study is to study the prevalence of subclinical hypothyroidism and its association with dyslipidemia. Thyroid hormone maintains the development and metabolism of the body. Thyroid dysfunction has been associated with complications like infertility, diastolic hypertension, ischemic heart disease, psychiatric disorders. 1157 sub-jects attending the NRI Hospital, Guntur for routine check up were taken into study. The patients were not under any medication. TSH and lipid profile was determined for all the subjects. The thyroid screening was done on Centaur CP and lipid profile on Dade Behring autoanalyzer. FT4 was estimated in subjects with TSH level 5.5 to 10μIU/ml to confirm SCH. Result: The prevalence of Subclinical Hypothyroidism (SCH) was 8.29% and the SCH was associated with increased dyslipidemia. Total cholesterol, triglyceride, LDL were raised up to 317 mg/dl, 575mg/dl and 201mg/dl respectively. TSH level significantly correlated with total cholesterol and LDL cholesterol.