ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Possible involvement of cyclooxygenase-2 in the recurrence of desmoid fibromatosis: case series and mini-review of the literature

Background: Desmoid fibromatosis (DF) is a type of fibrous tumor that rarely metastasizes but often recurs locally. Cyclooxygenase-2 (COX-2) has been shown to be expressed in DF lesions, although its involvement in DF recurrence is unknown. We investigated the association between COX-2 expression and DF recurrence using immunohistochemistry.

Patients and Methods: Cases of DF treated in our hospital between March 2000 and December 2012 were reviewed. We used immunohistochemistry to identify COX-2 expression in resected specimens from these cases. The relationship between recurrence and age, sex, duration of disease, size of tumor, tumor site, spontaneous pain, inflammation, and COX-2 expression was studied.

Results: In the ten included cases (mean age, 55.2 y; 5 male and 5 female patients), we found that COX-2 expression was significantly associated with DF recurrence (p=0.01).

Conclusion: Our findings indicate that COX-2 is involved in recurrence of DF.


Author(s): Kazuhiko Hashimoto, Shunji Nishimura, Naohiro Oka, Ryosuke Kakinoki, Masao Akagi

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+