It is known that control of procedural pain in newborns is an ethical act and requires treatment. It includes homeopathic agents used in certain clinical conditions in neonatology. The purpose of this prospective study is to determine the effect of administration of the preparation of Arnica D30 to reduce the severity of procedural pain induced by pricking the heel of the newborn in neonatal screening. Performed in a clinical study of 124 full-term infants aged 72-84 hours divided into two groups: the first group (A) n=67 infants, that do not apply anesthesia and a second group (B) n=57 infants receiving Arnica D30 in the form of an oral solution three times on the day of the procedure and a time in the range 12-24 hours after the procedure. The results are reported in: 30th sec. and the 5th minute after the puncture of the heel. The same indices were followed in the interval 12-24 hours after the screening. The 30th second after the penetration in the heel in Group A and Group B children did not reveal any credible differences on any of the scale indicators as well as the overall assessment of the severity of procedural pain. Comparison between the two groups of the 5th minute after the procedure found lower estimates in group ? (with analgesia). These differences between the groups are also valid for the overall score, which showed lower levels for those who have received an Arnica. The use of Arnica D30 affects the severity of procedural pain in neonates.