In the present study to investigate cardiac oxidative stress and evaluate the role of oxidant we measured lipid peroxides in terms of Malondialdehye and antioxidants namely total antioxidant capacity (TAC), vitamin C, glutathione peroxidase (GPx) and superoxide dismutase (SOD) in normal controls and different groups of Coronary artery disease patients, before and after treatment and after supplementation of oral dose of A – Z antioxidant tablets along with regular treatment. A significant increase in levels of serum lipid peroxide was observed in various groups of CAD patients when compared to control with concomitant fall in TAC, Vit C, GPx and SOD levels. The levels of lipid peroxides depleted after regular treatment in CAD, but failed to reach the control levels. Similarly the TAC, Vit C, SOD, and GPx, levels increased after regular treatment but the rise was not up to control values. However decrease in serum lipid peroxide and increase in the levels of TAC, Vit C, GPx and SOD up to control levels were found in patients subjected to oral dose of A – Z antioxidant tablets along with regular treatment. Thus the study brings to focus the significant role of antioxidant in inhibiting the oxidation of LDL and preventing initiation of lipid peroxidation in CAD. Hence, a management strategy aiming at reduction of lipid peroxidation in CAD is envisaged.