ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Isolation of Excretory Secretory Protein 6 kda antigen (ES-6) and its seroreactivity in patients with different stages of pulmonary tuberculosis and healthy household contacts

An Excretory Secretory protein antigen of 6 kDa (ES-6) was isolated from Mycobacterium tuberculosis H37Ra culture filtrate by gel filtration using fast protein liquid chromatography. Seroreactivity of ES-6 antigen was compared with earlier reported diagnostically useful ES-31 and ES-43 antigens at different stage of pulmonary tuberculosis and in household contacts of the patients. The ES-31 and ES-43 antigens showed good immune response in chronic and relapse cases respectively while ES-6 antigen has shown comparatively low immune response in these cases. However ES-6 showed in-creased seroreactivity in household contacts of pulmonary tuberculosis patients. These results suggest the heterogeneous responses of antigens in different disease conditions and immune response to ES-6 antigen may be associated with latent infection for predicting active disease in course of time, as observed in the follow up of these individuals.


Author(s): Sonika Gupta, Niraj Shende, Satish Kumar and B.C. Harinath

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+