The Fine-Needle Aspiration Cytology (FNAC) of salivary glands provides essential information in making clinical decisions. The purpose of this study is to assess the efficacy of FNAC in the pre-surgical diagnosis of salivary glands, comparing it to the final histopathological study. FNACs and biopsies collected from patients from 2000-2013 period, were compared finding a total of 433 salivary gland lesions. Of the 433 salivary gland lesions in our study, FNAC was developed on just 22.8% of lesions, 96.9% were satisfactory. 78 benign and 17 malignant lesions were diagnosed. In the histopathological study of lesions, 80 were diagnosed as benign and 18 as malignant. We found 14 true positive cases, 74 true negatives, 3 false positives and 4 false negatives. The diagnostic indexes included a FNAC sensitivity of 77% and a specificity of 96.1%. A Positive Predictive Value (PPV) of 82.35% and a Negative Predictive Value (NPV) of 94.8%. For the diagnosis of salivary gland lesions, FNAC showed high sensitivity and specificity in our sample, and the level of agreement between the FNAC diagnosis and the final diagnosis is good.