Biomedical Research

Background: This is a Clinical Randomized Trail (RCT) to explore the metastatic bone pain treatment effect of hyperthermia combined with pamidronate disodium, for improving the quality of life who suffered from the metastatic bone disease.

Method: A total of 60 patients with metastatic bone pain were divided into two groups, 30 patients in each group: the patients in treatment group were treated with hyperthermia combined with pamidronate disodium, and the patients in control group were treated with pamidronate disodium only. The effect of treatment and the quality of life was observed in the fourth week.

Results: The effective rate of treatment group and the control group were 93.33% and 63.33% respectively, and the difference in the two groups was significance (χ2=8.235, P=0.016), the NCCN score of life quality showed that, the quality of life in two groups was improved after treatment, and the degree of improvement was more significant in treatment group. Then it was showed that the alkaline phosphatase levels in two group were all declined after treatment (P=0.021).

Conclusion: The treatment effect of hyperthermia combined with pamidronate disodium is better than that treated with pamidronate disodium only. We can consider the combination of hyperthermia with pamidronate disodium as a method to treat metastatic bone pain in clinical practice.

Author(s): Fanlei Kong, Zhihong Nie, Zhongpo Liu, Shibin Hou, Jiangfeng Ji
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