The aim of the present study is to observe the effects of multimodal analgesia (MMA) for postoperative pain on patients with lower limb fractures. One hundred patients (American Society of Anesthesiology I~II, ASAI~II) with lower limb fractures, undergoing open reduction and internal fixation, under combined spinal and epidural analgesia (CSEA) were randomly divided into four groups: Control group (group C) and MMA groups I, II and III. All groups were administered IV fentanyl, for analgesia, after operation. The patients were followed up 6, 12 and 24h after operation and (visual analog scale) VAS score, fentanyl dose, pethidine frequency and adverse reactions were assessed. Results showed that, 12h, 24h VAS score, and 24h fentanyl dose of MMA group III were much lower than those of MMA groups I and II, while all of these were remarkably lower than those of group C (P<0.05). There were no statistically significant differences in pethidine frequency and adverse reactions at 24h among the four groups (P >0.05). It may be concluded that multimodal analgesia can effectively relieve postoperative pain in lower limb surgery.