The present study was planned to test the efficacy of Moringa oleifera on undesirable skin sebum secreted by sebaceous glands during winter season in humans. For this purpose, an extract of Moringa leaves was prepared due to strong antioxidant activity. 3% Moringa leaves extract was incorporated in active cream and the base was without extract. The study was conducted during the winter season (October to January). A total of eleven healthy male volunteers with aged 20 to 35 years were contributed to accomplish this single blind study. The active cream and base were applied twice daily to the face (cheeks) for a period of 12 weeks. Also, the antioxidant activity of the plant extract alone and after addition in the creams was assessed using the stable free radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay. The instrumental measurements were carried out with photometric device (Sebumeter) with relative humidity (55–65%). The Moringa oleifera cream significantly reduces undesirable skin sebum during winter season in humans when applied ANOVA and paired t-sample test. Treatment with Moringa oleifera showed reduction of undesirable skin sebum secretions secreted by sebaceous glands during winter season in humans.