Objective: To explore the difference of IL-4, IFN-γ in serum and LTE4 in urine between young and middle-aged patients with eczema and normal volunteers and its clinical significance.
Methods: We selected 84 cases of young and middle-aged patients with eczema treated in our hospital from April 2013 to April 2015. In control group, 50 cases of healthy volunteers who came for medical examination in our hospital in the same period were selected. IL-4, IFN-γ in serum and LTE4 in urine in both groups were detected.
Results: IL-4, IFN-γ in serum and LTE4 in urine in patients with eczema were significantly higher than that in control group (p<0.05). The difference of IL-4, IFN-γ and LTE4 levels among different grades of eczema were significant (p<0.05). The levels were the highest in acute eczema patients, and lowest in chronic eczema patients. There was no significant difference of albumin, erythrocyte sedimentation rate, serum creatinine, globulin, platelets and lymphocytes between eczema group and control group (p>0.05).
Conclusion: IL-4, IFN-γ in serum and LTE4 in urine in young and middle-aged patients with eczema significantly increase along with the degree of illness, indicating that IL-4, IFN-γ in serum and LTE4 in urine might be involved in pathogenesis of eczema.