Biomedical Research

Objective: To explore the value of 18F-deoxyglucose (¹⁸F-FDG) PET/CT in diagnosing distant lymph node metastasis of gynecological malignancies.

Method: 28 patients, initially confirmed with gynecological malignancies using pathological examination and other examinations-related, were enrolled in the study. They all underwent operation, and received preoperative ¹⁸F-FDG PET/CT scan and postoperative pathological examination. The findings of pathological examination were defined as the golden standard of diagnosis. The accuracy, specialty, and sensitivity of the routine CT and ¹⁸F-FDG PET/CT in diagnosing distant lymph node metastasis were counted. The maximal standard uptake value (SUXmax) of the patients with or without distant lymph node metastasis was compared.

Results: In 28 patients with gynecological malignancies diagnosed by postoperative pathological examination, 13 (46.43%) were confirmed with distal lymph node metastasis, and 15 (53.57%) without it. The accuracy, specialty, and sensitivity of ¹⁸F-FDG PET/CT was 82.14%, 100.00%, and 61.54% in separate, and that of the routine CT which was 50.00%, 73.33%, and 23.08%, respectively. ¹⁸F-FDG PET/CT had higher accuracy, specialty, and sensitivity than the routine CT, with a significant difference (P<0.05). Compared the SUVmax in the patients with or without distant lymph node metastasis, there was no statistical difference (P>0.05).

Conclusion: ¹⁸F-FDG PET/CT has higher accuracy in detecting distant lymph node metastasis of gynecological malignancies, and provides favorable guidance for clinical practice, deserving spread.

Author(s): Wang Jiafu, Zhang Linhan, Wu Di, Li Yong
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