Biomedical Research

This study endeavours to correlate levels of TNF-alpha and other co-variates (BMI; abnormal lipids; blood sugar; microalbuminuria) and different grades of blood pressure in essential hypertensive patients. Sixty newly detected patients of Essential Hypertension were recruited in the study. It comprised of 36 males and 24 females categorized into stage 1 or stage 2 hypertension. TNF-alpha levels were consistently found to be elevated in both the stages of hypertension. Though females in the study had slightly higher mean values of TNF- alpha than the males, the difference was not statistically significant (p>0.05). No significant correlation was observed between levels of TNF- alpha and stage of hypertension (p>0.05). Using Pearson’s Correlation coefficient, TNF-alpha levels were found to significantly correlate with LDL (p<0.05) and BMI (p<0.001).

Author(s): Khan SA, Aslam M, Owais M, Zaheer MS
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