Soft-Computing (SC) exemplifies the vague elucidation for almost all computational tasks, but still it is said to be the epitome of various schemas such as Fuzzy Logic (FL), Neural Networks (NN), and Genetic Algorithms (GA) for manipulating data. SC schemas can be combined, which we have termed as Combined Schema. There is a gradual, yet study growth in the arena of bio-informatics, biochemistry, various engineering and science domain, with the aid of this combined schema through analysis and various technical computations. The main perspective of this paper is to have a study of various SC methodologies with its application. In recent years, most of the medical developments are carried off by the computational methodologies such as soft computing, which act as a basis for the practice of modern medicine. The search rate of MEDLINE projects that, more than 65% of FL with NN, less than 25% of GA with NN and less than 5% of GA with FL, which is also predicted by the fact that most of the medical searches in MEDLINE are being made on the basis of SC methodologies.