Neuroendocrine Tumours (NEC), are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. Many are benign, while some are malignant. They most commonly occur in the lung, intestine, where they are often called carcinoid tumours, but they are also found in the pancreas, and the rest of the body. The female genital counterpart is aggressive and uncommon, with propensity to involve the cervix and ovary, the endometrium variant is seldom occurring and tends to be of a conventional small cell type (up to 60 cases). Only twelve cases of large cell type NEC. In our centre, we diagnose a case of Large-Cell Neuroendocrine Carcinoma (LCNEC) of the, endometrium in an 82 y old female. It was report it as mixed type tumour papillary serous and large neuroendocrine, with FIGO nuclear grade III, the endocrine origin of the tumour was confirmed by immunohistochemically endocrine marker CD56 and NSE. Patient medical condition was unfit for surgery and she chose palliative treatment.