ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

Abstract

Clinical effects of recombinant human BNP in treating acute heart failure and study on its effects On TWEAK and nT-pro BNP

Objective: To observe the level changes of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and amino-terminal pro-B-type natriuretic peptide (NT-proBNP) of Acute Heart Failure (AHF) patients and re-evaluate the clinical effects and safety of recombinant human brain natriuretic peptide (rhBNP) in treating AHF.

Methods: 89 cases with AHF in our hospital and 40 healthy volunteers were recruited as the control group. The differences of TWEAK and NT-pro BNP of patients in two groups were observed and compared. Patients in AHF group were divided into subgroup. 24 cases in routine subgroup given routine anti-HF and anti-basic disease treatment. 47 cases in rhBNP subgroup given routine treatment and rhBNP treatment over 72 h.

Results: TWEAK and NT-pro BNP level of serum of patients in AHF group were (157.6 ± 69.7 pg/ml) and (3124.2 ± 2713.5 pg/ml) separately, significantly higher than the control group, there were statistical differences, P<0.01. TWEAK and NT-pro BNP level of patients in routine subgroup and rhBNP subgroup before treatment were similar, there were no statistical differences, P>0.05. After treatment, various detection indexes of patients in AHF group significantly improved compared with before treatment. TWEAK and NT-pro BNP level of serum of patients in TWEAK and NT-pro BNP level were (72.8 ± 34.5 pg/ml) and (769.2 ± 518.5 pg/ml) separately, there were statistical differences compared with patients in routine subgroup, P<0.05. The total effective rate of patients in routine subgroup was 71.43%, obviously lower than rhBNP subgroup (89.36%), there were statistical differences, P<0.05. There were 4 patients adverse events and 5 death patients in routine subgroup. There were 2 cases with hypotension and 2 death cases in rhBNP subgroup.

Conclusion: Recombinant human BNP can effectively treat CHF, rapidly improve clinical symptoms of patients and laboratory biochemical indexes such as TWEAK and NT-pro BNP etc. Compared with routine treatment methods, it has significant effects and high safety. It is worthy of clinical promotion.

Author(s): Li Jing, Yuan Yiqiang, Zhang Li, Zhang Shenwei, Zhang Yu, Zhang Hua, Wang Mingjie, Zhang Jinying
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