The objective of the present study is to investigate the relationship between the lesion characteristics of coronary artery and risk factors of coronary heart disease (CHD). A total of 430 patients underwent coronary angiography (CAG) were recruited from January 2008 to October 2009 and divided into CHD group (n=282) and non-CHD group (control group, n=148) according to the findings on CAG. The risk factors of CHD including smoking, hypertension, hyperlipemia and diabetes mellitus (DM) were recorded. Multivariable regression analysis was employed for the analysis of correlation between risk factors and lesion characteristics of coronary artery. The systolic pressure, pulse pressure, hypersensitive C reaction protein (hs-CRP), plasma fibrinogen and glycosylated hemoglobin (HbA1c) in the CHD group were markedly higher than those in the control group (P<0.01). Gender, age, hypertriglyceridemia, DM and elevated plasma fibrinogen are the independent risk factors of CHD (P<0.05) and also closely related to the extent and score of lesion in CHD patients. Subjects who are male or smokers, or have DM, hypertriglyceridemia or elevated hs-CRP / plasma fibrinogen have high risk for CHD.