Carriage rate of HIV infection among ABO and rhesus blood groups was conducted on one thousand five hundred and twenty subjects randomly selected from fifteen health institu-tions in Adamawa State. Prior to the enrollment of the subjects in the study, ethical ap-proval of the health institutions was obtained and the informed consent of the subjects sought. One thousand and thirty apparently healthy subjects were enrolled as test group while another 490 known subjects were enrolled as control group. 5ml of blood sample was collected from each subject, out which 3ml was put in plain container to extract serum needed for HIV serotyping, while the remaining 2ml was put in EDTA container for blood grouping. Analysis of ABO blood group system showed a higher distribution (50.6%) of group O and the lowest (11.7%) of group AB individuals. Statistical analysis however showed no significant difference in the distribution of ABO blood groups in the state (P>0.05). The overall prevalence of HIV infection was 12.6%. Statistically, there was signifi-cant difference in the prevalence of HIV sero-types in the state (P<0.05). Also, Blood group AB recorded the highest rate of HIV-2 infection (71.4%) and the least prevalence of HIV-1 (7.1%) whereas seroprevalence of HIV sero-type was significantly higher among rhesus D positive subjects than their rhesus D negative counterparts (P<0.05).