Background: The relationship between blood pressure variability and stroke in progression (SIP) in acute ischemic stroke (AIS) or transient ischemic attack (TIA) is still controversial. The aim of this study was to evaluate the impact of blood pressure variability estimated by average real variability on SIP.
Method: We prospected enrolled 251 consecutive patients with AIS or TIA (within 7 days after onset). Blood pressure was measured at 2 h intervals throughout the first 24 h, then every 4 h up to the 7th day. Average real variability was used to represent blood pressure variability. Ischemic stroke (IS) patients with an increase of national institutes of health stroke scale ≥ 3 scores or TIA patients in the event of stroke within 7 days after admission were defined as stroke. Patients were grouped in low and high blood pressure average real variability groups.
Results: The incidence rate of SIP was 8.3%. In univariate analysis, high D2-7 systolic blood pressure average real variability, female, and high total cholesterol level were significantly associated with SIP. In multivariate logistic regression analysis, SIP was independently predicted by total cholesterol and high D2-7 systolic blood pressure average real variability.
Conclusion: High D2-7 systolic blood pressure average real variability was an independent predictor of SIP in AIS or TIA patients.